Ingenuity Pathways Analysis 5.0 Now Available
Ingenuity Systems has released IPA 5.0 software, the first software of its kind to offer specific functions for identifying biomarker candidates and characterizing molecular toxicity in a biological context. IPA-Biomarker and IPA-Tox, within the IPA application, enable researchers to mechanistically connect biomarkers to pathways of disease and drug response and elucidate toxic effects not revealed by traditional methods. IPA 5.0 also contains an extensive addition of new expert-extracted content from the scientific literature, including new knowledge about diseases, exogenous and endogenous chemicals, and drugs and clinical candidates.
New features of IPA 5.0 include:
- IPA-Biomarker, designed to:
- Identify and prioritize the most promising biomarker candidates from datasets
- Prioritize molecular biomarker candidates based on key biological characteristics
- Perform analysis across biomarker lists to find biomarker candidates unique to a disease stage or common across all stages
- Elucidate mechanisms linking potential markers to a disease or biological process of interest
- Understand the molecular differences between patient populations
- IPA-Tox, designed to:
- Assess the toxicity and safety of compounds of interest early in the development process
- Provide expert molecular toxicology data interpretation to non-expert users
- Reveal clinical pathology endpoints associated with a dataset
- Generate new hypotheses that may not have been revealed using traditional toxicology approaches
- Elucidate mechanism of toxicity and identify potential markers of toxicity
- Easily access important findings from the scientific literature, including information associated with cardiovascular toxicity, nephrotoxicity, and hepatotoxicity
- Improved Tools for Biological Interpretation and Communication
- Increased Expert-Extracted Content
Access to IPA during the 2007 fiscal year is free for the entire medical school community. Access is unrestricted through May 2007, after which only two concurrent users will be allowed at a time. To request access to IPA, please send an email to Pat Gunn at gunnp@wustl.edu with the following information:
Name
Department
Phone Number
Campus Box
After registration, Ingenuity Systems will send each registrant, via e-mail, their individual password and login instructions.
Please note, the first time you login to your IPA account, it may take a few minutes to load the application. Additionally, please disable all pop-up blockers prior to signing in as they may prevent the application from loading.
For technical questions, please contact Dr. Lili Wang at 314-362-7085 or Dr. Kristi Holmes at 314-362-4737.
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